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HA14-1

CAT: 0013-GTR19161089-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161089-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells; effectively induces apoptosis of HL-60 cells overexpressing Bcl-2 protein associated with the decrease in mitochondrial membrane potential and activation of caspase-9 followed by caspase-3; strongly induces the death of NIH 3T3 (Apaf-1 (+/+) ) cells.
CAS Number
65673-63-4
Product Name Alternative
HA-14-1 | HA 14-1
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C1=C (N) OC2=C (C=C (Br) C=C2) [C@H]1[C@H] (C#N) C (OCC) =O) OCC
Molecular Formula
C17H17BrN2O5
Molecular Weight
409.2313
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-.alpha.-cyano-3- (ethoxycarbonyl) -, ethyl ester, (.alpha.R,4R) -rel-

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CatalogName
A8168-50HA14-1

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