Products for Research Use Only

LF3

CAT: 0013-GTR19161064-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161064-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A small-molecule antagonist of the β-catenin/TCF4 interaction with IC50 of 1.65 and 1.82 uM in AlphaScreen and ELISA assay, respectively; potently and selectively inhibits activated Wnt/β-catenin signals in reporter cells (IC50=2.4-4 uM), does not cause cell death and interfere with the interaction of β-catenin with E-cadherin; reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer.
CAS Number
664969-54-4
Product Name Alternative
LF-3 | LF 3
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
S=C (N1CCN (C/C=C/C2=CC=CC=C2) CC1) NC3=CC=C (S (=O) (N) =O) C=C3
Molecular Formula
C20H24N4O2S2
Molecular Weight
416.56016
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperazinecarbothioamide, N-[4- (aminosulfonyl) phenyl]-4- (3-phenyl-2-propen-1-yl) -