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Terconazole

CAT: 0013-GTR19161030-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161030-05Size:100 mg
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Description
Arecoline is a muscarinic acetylcholine receptor agonist. Arecoline induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells. (In Vitro) :Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10 μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL. (In Vivo) :A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole.
CAS Number
67915-31-5
Product Name Alternative
NSC 331942 | R-42470 | (±) -Terconazole
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
CC (N1CCN (C2=CC=C (OC[C@H]3O[C@] (CN4N=CN=C4) (C5=CC=C (Cl) C=C5Cl) OC3) C=C2) CC1) C
Molecular Formula
C26H31Cl2N5O3
Molecular Weight
532.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4- (((2S,4R) -2- ((1H-1,2,4-triazol-1-yl) methyl) -2- (2,4-dichlorophenyl) -1,3-dioxolan-4-yl) methoxy) phenyl) -4-isopropylpiperazine

Chemical Information

Terconazole

(2R,4S)-terconazole is a 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine in which positions 2 and 4 of the 1,3-dioxolane moiety have R and S configuration, respectively. It is an enantiomer of a (2S,4R)-terconazole.

CAS Number67915-31-5
PubChem CID441383
IUPAC Name1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine
Molecular FormulaC26H31Cl2N5O3
Molecular Weight532.5
XLogP4.8
Topological Polar Surface Area64.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count36
Formal Charge0
Complexity692
SMILES
CC(C)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
InChI
InChI=1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1
InChIKey
BLSQLHNBWJLIBQ-OZXSUGGESA-N
Chemical Structure
2D Structure
2D structure of Terconazole
CAS: 67915-31-5
CID: 441383
Formula: C26H31Cl2N5O3
MW: 532.5
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight532.5
XLogP34.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass531.1803953
Monoisotopic Mass531.1803953
Topological Polar Surface Area64.9 Ų
Heavy Atom Count36
Formal Charge0
Complexity692
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA1672-5.1Terconazole
AR-T04495-01Terconazole-d8
HY-B1790R-01Terconazole (Standard)
467000-01Terconazole-d4

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