Products for Research Use Only
RegisterLogin

Vitamin D3

CAT: 0013-GTR19161028-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19161028-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cholecalciferol is a naturally occuring form of vitamin D. Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of Y cells. (In Vitro) :Vitamin D3 is an inactive vitamin D molecule in vivo. Vitamin D3 undergoes two hydroxylation processes to activate it. Vitamin D3 is first hydroxylated in the liver to form the circulating prohormone 25-hydroxy vitamin D3 [25 (OH) D3] by the enzyme 25-hydroxylase (CYP27A1) and probably also by other enzymes (e.g., CYP2R1) .The second hydroxylation occurs in the kidneys via the enzyme 1-alpha-hydroxylase, yielding 1,25- dihydroxycholecalciferol (calcitriol), which is the biologically active form of vitamin D.Vitamin D3 (2-10 μM; 24-48 hours) exhibits anti-proliferative effects in a dose- and time- dependent manner. Maximal reduction of viability post treatment of 62% (IK), 52% (RL-95-2), and 55% (Hec-1A) occurrs by 72 h of treatment with 10 μM Vitamin D3. but 24-hour exposure lacks significant reduction in viable cells.Cholecalciferol (10 μM; 24-48 hours) shows marked increases in nuclear VDR staining and produces local VDR activation in IK cells. (In Vivo) :Cholecalciferol (oral gavage; 5 mg/kg; 7 days) potentiates the CCl4 toxicity only in the liver, as indicated by plasma levels of ALT and AST, biochemical markers of hepatic damage. It significantly increases renal calcium levels in mice, but renal calcium content does not differ significantly between mice.
CAS Number
67-97-0
Product Name Alternative
Cholecalciferol | NSC 375571
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C[C@H] (CCCC (C) C) [C@H]1CC[C@@H]\2[C@@]1 (CCC/C2=C\C=C/3\C[C@H] (CCC3=C) O) C
Molecular Formula
C27H44O
Molecular Weight
384.64
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S, Z) -3- (2- ((1R,3aS,7aR, E) -7a-methyl-1- ((R) -6-methylheptan-2-yl) octahydro-4H-inden-4-ylidene) ethylidene) -4-methylenecyclohexan-1-ol

Related Products

CatalogName
GTR1785529025 Vitamin D2 & D3 Monoclonal Antibody (Capture)
GTR18404527-01Antibody to vitamine D3
GTR19161017-01Vitamin A
GTR19283544Vitamin A
GTR18195115-01Biotin (Vitamin B7 or Vitamin H) Antibody
GTR18195114-01Biotin (Vitamin B7 or Vitamin H) Antibody
GTR18192966-01Biotin (Vitamin B7 or Vitamin H) Antibody
GTR18195116-01Biotin (Vitamin B7 or Vitamin H) Antibody
GTR18192998-01Biotin (Vitamin B7 or Vitamin H) Antibody
GTR19217292-01Vitamin B6

Alternative Products

CatalogName
MBS3842470-01Vitamin A
MBS4380419-01Biotin (Vitamin B7 or Vitamin H)
172035-01Biotin (Vitamin B7, Vitamin H)
046187Biotin (Vitamin H, Vitamin B7)
1703-01RIBOFLAVIN (Vitamin B2), Vitamin G2
AR-V01550-01Vitamin A Impurity C (retro-Vitamin A)
172035-AF-BiotinBiotin (Vitamin B7, Vitamin H) (Biotin)
168650-AF-HRPBiotin (Vitamin B7, Vitamin H) (HRP)
MBS6122548-01Biotin (Vitamin B7, Vitamin H) (PE)
MBS6122544-01Biotin (Vitamin B7, Vitamin H) (APC)

Popular Products