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Tideglusib

CAT: 0013-GTR19160970-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160970-01Size:1 g
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Description
Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2. (In Vitro) :Incubation of both astrocyte and microglial cultures with Tideglusib (NP031112) completely abrogates the induction of TNF-α and COX-2 expression after glutamate treatment. These effects of NP031112 are not caused by a loss of cell viability, because the 24 h exposure of astrocyte and microglial cells to this TDZD does not modify cell viability. (In Vivo) :Injection of Tideglusib (NP031112) (50 mg/kg) into the rat hippocampus dramatically reduces kainic acid-induced inflammation, as measured by edema formation using T2-weighted magnetic resonance imaging and glial activation and has a neuroprotective effect in the damaged areas of the hippocampus.
CAS Number
865854-05-3
Product Name Alternative
NP031112
Purity
>98% (HPLC)
Solubility
DMSO: 1 mg/mL (2.99 mM)
Smiles
O=C (N1CC2=CC=CC=C2) N (C3=C4C=CC=CC4=CC=C3) SC1=O
Molecular Formula
C19H14N2O2S
Molecular Weight
334.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (1-naphthalenyl) -4- (phenylmethyl) -1,2,4-thiadiazolidine-3,5-dione

Alternative Products

CatalogName
C08890-5gTideglusib

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