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PF 573228

CAT: 0013-GTR19160958-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160958-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. (In Vitro) :PF-573228 inhibits purified recombinant catalytic fragment of FAK with an IC50 of 4 nM. In cultured cells, PF-573228 inhibits FAK phosphorylation on Tyr397 with an IC50 of 30-100 nM. Treatment of cells with concentrations of PF-573228 that significantly decreased FAK Tyr397 phosphorylation fails to inhibit cell growth or induce apoptosis. In contrast, treatment with PF-573228 inhibits both chemotactic and haptotactic migration concomitant with the inhibition of focal adhesion turnover.
CAS Number
869288-64-2
Product Name Alternative
FAK Inhibitor II | Focal Adhesion Kinase Inhibitor II
Purity
>98% (HPLC)
Solubility
DMSO: 26 mg/mL (52.9 mM)
Smiles
O=C1NC2=C (C=C (NC3=NC=C (C (F) (F) F) C (NCC4=CC=CC (S (=O) (C) =O) =C4) =N3) C=C2) CC1
Molecular Formula
C22H20F3N5O3S
Molecular Weight
491.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone

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