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Fevipiprant

CAT: 0013-GTR19160943-03Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160943-03Size:5 mg
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Description
A slowly dissociating CRTh2 antagonist with Kd of 1.14 nM; shows a half-life of 14.4 minutes, >7-fold slower than AZD-1981; inhibits PGD2-stimulated human eosinophil shape change, importantly, retains its potency in the whole-blood shape-change assay relative to the isolated shape change assay; also is a potent inhibitor of PGD2-induced cytokine release in human Th2 cells.Asthma Phase 3 Clinical (In Vitro) :Fevipiprant (0-10 μM) inhibits the gene expression of IL-4, IL-3, IL-5, IL-8, CSF1, CSF2 in n in human Th2 cells induced by activated mast cell supernatants. (In Vivo) :Fevipiprant (10 mg/kg; in the drinking water) reduces CaCl2-induced AAA (abdominal aortic aneurysm) formation in mouse.
CAS Number
872365-14-5
Product Name Alternative
NVP-QAW039 | QAW-039
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (O) CC1=C (C) N (CC2=CC=C (S (=O) (C) =O) C=C2C (F) (F) F) C3=NC=CC=C31
Molecular Formula
C19H17F3N2O4S
Molecular Weight
426.4095
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 2-methyl-1-[[4- (methylsulfonyl) -2- (trifluoromethyl) phenyl]methyl]-

Chemical Information

Fevipiprant

Fevipiprant has been used in trials studying the treatment of Asthma, Atopic Dermatitis, and Allergic Rhinitis.

CAS Number872365-14-5
PubChem CID23582412
IUPAC Name2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]acetic acid
Molecular FormulaC19H17F3N2O4S
Molecular Weight426.4
XLogP2.8
Topological Polar Surface Area97.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity709
SMILES
CC1=C(C2=C(N1CC3=C(C=C(C=C3)S(=O)(=O)C)C(F)(F)F)N=CC=C2)CC(=O)O
InChI
InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
InChIKey
GFPPXZDRVCSVNR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Fevipiprant
CAS: 872365-14-5
CID: 23582412
Formula: C19H17F3N2O4S
MW: 426.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight426.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass426.08611269
Monoisotopic Mass426.08611269
Topological Polar Surface Area97.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity709
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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