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Serdemetan

CAT: 0013-GTR19160909-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160909-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serdemetan (JNJ 26854165) is a novel anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM; induces p53-mediated apoptosis in acute leukemia cells with wild-type p53, accelerates the proteasome-mediated degradation of p21 and antagonizes the transcriptional induction of p21 by p53, induces S-phase delay and upregulates E2F1 expression in p53 mutant cells; demonstrates radiosensitizing activity in vitro and in tumor xenografts.Lung Cancer Phase 1 Discontinued.
CAS Number
881202-45-5
Product Name Alternative
JNJ 26854165 | JNJ26854165 | JNJ-26854165
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1 (NCCC2=CNC3=C2C=CC=C3) =CC=C (NC4=CC=NC=C4) C=C1
Molecular Formula
C21H20N4
Molecular Weight
328.4103
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,4-Benzenediamine, N1-[2- (1H-indol-3-yl) ethyl]-N4-4-pyridinyl-

Alternative Products

CatalogName
BUP09761-01Serdemetan
A4204-100JNJ-26854165 (Serdemetan)
C16160-100mgSerdemetan (JNJ-26854165)

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