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CCT128930

CAT: 0013-GTR19160898-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160898-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6 nM (AKT2), 28-fold selectivity over the closely related PKA; also exhibits 20-fold selectivity over p70S6K (IC50=120 nM) ; shows growth inhibition for U87MG human glioblastoma cells (IC50=6.3 uM), for LNCaP human prostate cancer cells (IC50=0.35 uM), and for PC3 human prostate cancer cells (IC50=1.9 uM) consistent with AKT pathway blockade; blocks the phosphorylation of several downstream AKT biomarkers in U87MG tumor xenografts, indicating AKT inhibition in vivo; demonstrates antitumor activity in U87MG and HER2-positive, PIK3CA-mutant BT474 human breast cancer xenografts.
CAS Number
885499-61-6
Product Name Alternative
CCT 128930 | CCT-128930
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
NC1 (CC2=CC=C (Cl) C=C2) CCN (C3=C4C (NC=C4) =NC=N3) CC1
Molecular Formula
C18H20ClN5
Molecular Weight
341.8
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Piperidinamine, 4-[ (4-chlorophenyl) methyl]-1- (7H-pyrrolo[2,3-d]pyrimidin-4-yl) -

Alternative Products

CatalogName
B1763-1CCT128930

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