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CDN1163

CAT: 0013-GTR19160881-08Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160881-08Size:50 mg
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Description
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes; increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells; improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice; CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers.
CAS Number
892711-75-0
Product Name Alternative
CDN 1163 | CDN-1163
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL 156.06 mM; H2O : < 0.1 mg/mL
Smiles
O=C (NC1=C2N=C (C) C=CC2=CC=C1) C3=CC=C (OC (C) C) C=C3
Molecular Formula
C20H20N2O2
Molecular Weight
320.392
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (1-Methylethoxy) -N- (2-methyl-8-quinolinyl) benzamide

Chemical Information

Cdn1163

CDN1163 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-isopropoxybenzoic acid with the primary amino group of 2-methylquinolin-8-amine. An allosteric activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). It has a role as a SERCA activator. It is a secondary carboxamide, a member of quinolines and an aromatic ether.

CAS Number892711-75-0
PubChem CID16016585
IUPAC NameN-(2-methylquinolin-8-yl)-4-propan-2-yloxybenzamide
Molecular FormulaC20H20N2O2
Molecular Weight320.4
XLogP4.2
Topological Polar Surface Area51.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity418
SMILES
CC1=NC2=C(C=CC=C2NC(=O)C3=CC=C(C=C3)OC(C)C)C=C1
InChI
InChI=1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)
InChIKey
GVGVYDCVFBGALZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cdn1163
CAS: 892711-75-0
CID: 16016585
Formula: C20H20N2O2
MW: 320.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.4
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass320.152477885
Monoisotopic Mass320.152477885
Topological Polar Surface Area51.2 Ų
Heavy Atom Count24
Formal Charge0
Complexity418
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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B8455-5CDN1163
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