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KX2-391

CAT: 0013-GTR19160872-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160872-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KX2-391, the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Phase 2. (In Vitro) :Tirbanibulin (KX2-391) is a Src inhibitor that is directed to the Src substrate pocket. Tirbanibulin (KX2-391) shows steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines. Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin (KX2-391) is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively. (In Vivo) :Orally administered Tirbanibulin (KX2-391) is shown to inhibit primary tumor growth and to suppress metastasis, in pre-clinical animal models of cancer.
CAS Number
897016-82-9
Product Name Alternative
KX 01
Purity
>98% (HPLC)
Solubility
DMSO:86 mg/mL (199.29 mM) ; Ethanol:<1 mg/mL (<1 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
O=C (NCC1=CC=CC=C1) C2=NC=C (C3=CC=C (OCCN4CCOCC4) C=C3) C=C2
Molecular Formula
C26H29N3O3
Molecular Weight
431.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-benzyl-5- (4- (2-morpholinoethoxy) phenyl) picolinamide

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Alternative Products

CatalogName
B2282-5KX2-391
A3535-250KX2-391 dihydrochloride
MBS386797-01KX2-391 2HCl
A11177-25Tirbanibulin (KX2-391) 25mg
A11177-10Tirbanibulin (KX2-391) 10mg
A11471-10KX2-391 dihydrochloride 10mg
A11177-100Tirbanibulin (KX2-391) 100mg
A11471-25KX2-391 dihydrochloride 25mg
A11471-5KX2-391 dihydrochloride 5mg
A11177-500Tirbanibulin (KX2-391) 500mg

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