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SKL2001

CAT: 0013-GTR19160827-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160827-05Size:50 mg
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Description
SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction; strongly activates β-catenin responsive transcription, upregulates TOPflash reporter activity without effect on the activity of FOPFlash with mutated β-catenin/Tcf-binding elements, as well as either NF-κB or p53 reporter activity; upregulates the expression of Axin2, inhibits N-terminal β-catenin phosphorylation without affecting GSK-3β activity; suppresses preadipocyte differentiation, the alternative mesenchymal differentiation pathway. (In Vitro) :SKL2001 is an agonist of the Wnt/β-catenin pathway, and also upregulates the expression of Axin2, a downstream target of the Wnt/β-catenin pathway, but shows no effect on NF-κB, p53 reporter activity and GSK-3β activity. SKL2001 causes osteoblast differentiation (20 and 40 μM) and suppresses preadipocyte differentiation (5, 10, and 30 μM) via the activation of the Wnt/β-catenin pathway. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible; SKL2001 cuases cell cycle arrest in HCT116 spheroids. SKL2001 (40 μM) enhances round-shape spheroid formation and E-cadherin expression.
CAS Number
909089-13-0
Product Name Alternative
SKL 2001 | SKL-2001
Purity
>98% (HPLC)
Solubility
DMSO: 53 mg/mL (185.1 mM) ; Ethanol: 53 mg/mL (185.1 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1=NOC (C2=CC=CO2) =C1) NCCCN3C=CN=C3
Molecular Formula
C14H14N4O3
Molecular Weight
286.291
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl) -amide

Chemical Information

5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide

an agonist of the Wnt-beta-catenin pathway; structure in first source

CAS Number909089-13-0
PubChem CID16003447
IUPAC Name5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide
Molecular FormulaC14H14N4O3
Molecular Weight286.29
XLogP0.8
Topological Polar Surface Area86.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count21
Formal Charge0
Complexity355
SMILES
C1=COC(=C1)C2=CC(=NO2)C(=O)NCCCN3C=CN=C3
InChI
InChI=1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
InChIKey
PQXINDBPUDNMPE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide
CAS: 909089-13-0
CID: 16003447
Formula: C14H14N4O3
MW: 286.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight286.29
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass286.10659032
Monoisotopic Mass286.10659032
Topological Polar Surface Area86.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity355
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-101085-01SKL2001
A16707-200SKL2001 200mg

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