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MK-2461

CAT: 0013-GTR19160798-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160798-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-2461 is a potent multitargeted kinase inhibitor that preferentially inhibits c-Met with IC50 of 2.5 nM, with similar potencies for Ron and Flt1 (IC50=7 and 10 nM, respectively) ; 8- to 30-fold less sensitive to FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB; is equally or more potent against 5 c-Met mutants (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC50 of 0.4-2.5 nM; inhibits c-Met-dependent mitogenesis, migration, cell scatter, and tubulogenesis in cells; suppresses tumor growth a murine xenograft model of c-Met-dependent gastric cancer; orally active.Solid Tumors Phase 2 Clinical
CAS Number
917879-39-1
Product Name Alternative
MK 2461 | MK2461
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
O=S (NC1=CC=C2C (C (C3=CC (C4=CN (C) N=C4) =CN=C3C=C2) =O) =C1) (N (C[C@H]5OCCOC5) C) =O
Molecular Formula
C24H25N5O5S
Molecular Weight
495.5508
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sulfamide, N-[ (2R) -1,4-dioxan-2-ylmethyl]-N-methyl-N'-[3- (1-methyl-1H-pyrazol-4-yl) -5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-

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