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CNV1014802

CAT: 0013-GTR19160748-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160748-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.Pain Phase 2 Clinical (In Vitro) :Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the US Food and Drug Administration in July 2013.
CAS Number
934240-30-9
Product Name Alternative
GSK-1014802 | CNV-1014802 | Raxatrigine | Vixotrigine | BIIB074
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1CC (NC1C2=CC=C (C=C2) OCC3=CC=CC=C3F) C (=O) N
Molecular Formula
C18H19FN2O2
Molecular Weight
314.3541
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Pyrrolidinecarboxamide, 5-[4-[ (2-fluorophenyl) methoxy]phenyl]-, (2S,5R) -

Alternative Products

CatalogName
M16676-01CNV1014802
B5927-2GSK1014802(CNV1014802)
MBS3606671-01CNV1014802 hydrochloride
abx183951CNV1014802 (hydrochloride)

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