Glimepiride

CAT: 0013-GTR19160742-02Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19160742-02Size:500 mg

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Description

Glimepiride is the first III generation sulphonyl urea it is a very potent sulphonyl urea with long duration of action. (In Vivo) :Glimepiride (Glimperide) is a new sulfonylurea. After oral administration of Hoe 490 to rabbits, blood glucose was lowered 3.5 times more than after glibenclamide (HB 419) and after intravenous administration, 2.5 times more. Glimepiride (Glimperide) decreased extracellular Aβ40 and Aβ42 levels. glimepiride may serve as a promising drug for the treatment of AD associated with diabetes. Glimepiride (Glimperide) was generally associated with lower risk of hypoglycemia and less weight gain compared to other sulfonylureas. Glimepiride (Glimperide) use may be safer in patients with cardiovascular disease because of its lack of detrimental effects on ischemic preconditioning.

CAS Number

93479-97-1

Product Name Alternative

HOE 490

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

DMSO: 11 mg/mL (22.42 mM)

Smiles

CCC1=C (CN (C1=O) C (=O) NCCC2=CC=C (C=C2) S (=O) (=O) NC (=O) NC3CCC (CC3) C) C

Molecular Formula

C24H34N4O5S

Molecular Weight

490.62

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4-ethyl-3-methyl-N-[2-[4-[ (4-methylcyclohexyl) carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide

Chemical Information

1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-2-4-(trans-4-methylcyclohexyl)aminocarbonylaminosulfonylphenylethyl-2-oxo-

Glimepiride is a sulfonamide, a N-acylurea and a N-sulfonylurea. It has a role as a hypoglycemic agent and an insulin secretagogue.

CAS Number	93479-97-1
PubChem CID	3476
IUPAC Name	4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
Molecular Formula	C24H34N4O5S
Molecular Weight	490.6
XLogP	3.9
Topological Polar Surface Area	133
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Heavy Atom Count	34
Formal Charge	0
Complexity	895

SMILES

CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C

InChI

InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)

InChIKey

WIGIZIANZCJQQY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 93479-97-1

CID: 3476

Formula: C24H34N4O5S

MW: 490.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	490.6
XLogP3	3.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	490.22499137
Monoisotopic Mass	490.22499137
Topological Polar Surface Area	133 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	895
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
A4033-5.1	Glimepiride

Glimepiride

Chemical Information

Alternative Products

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