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LCZ-696

CAT: 0013-GTR19160730-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160730-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio) ; causes dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provides sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats; orally active.Heart Failure Approved (In Vitro) :Sacubitril/Valsartan (LCZ696; 1-30 μM; 0.5 hours) inhibits HG-treated H9C2 cells apoptosis in an experimental model of Diabetic cardiomyopathy (DCM) .Sacubitril/Valsartan (1-30 μM; 0.5 hours) increases the expression level of cleaved caspase-3 and the ratio of Bax/Bcl-2 in HG-treated H9C2 cells. (In Vivo) :Sacubitril/Valsartan (LCZ696; perorally; 68 mg/kg for 4 weeks) significantly exhibits small weights and reduces interstitial fibrosis both in the noninfarct zone and peri-infarct zone.
CAS Number
936623-90-4
Product Name Alternative
LCZ696 | LCZ 696
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) [C@@H] (C ([O-]) =O) N (C (CCCC) =O) CC1=CC=C (C2=CC=CC=C2C3=NN=N[N-]3) C=C1.O=C (OCC) [C@H] (C) C[C@H] (NC (CCC ([O-]) =O) =O) CC4=CC=C (C5=CC=CC=C5) C=C4.[Na+].[Na+].[Na+].O
Molecular Formula
C48H60N6Na3O10.5
Molecular Weight
957.99
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Valine, N- (1-oxopentyl) -N-[[2'- (2H-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR, γS) -γ-[ (3-carboxy-1-oxopropyl) amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)

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