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Roxatidine Acetate hydrochloride

CAT: 0013-GTR19160722-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160722-01Size:200 mg
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Description
Roxatidine Acetate hydrochloride is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation. (In Vitro) :Roxatidine Acetate Hydrochloride (0-120 μM, 1 h) suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.Roxatidine Acetate Hydrochloride (6.25 μM, 12.5 μM, and 25 μM; pre-treatment for 30 min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, and p38 MAPK levels are unaffected by roxatidine in human mast-cells-1 (HMC-1) cells. (In Vivo) :Roxatidine Acetate Hydrochloride (0-300 mg/kg; p.o.; 26 days) suppressed growth of Colon 38 tumor implants in mice.Roxatidine Acetate Hydrochloride (oral gavage; 20 mg/kg; single dose) inhibits Compound 48/80-increased TNF-α, IL-6, and IL-1β production and mRNA expression. Additionally, Roxatidine Acetate Hydrochloride decreases the compound 48/80-induced degradation of procaspase-1 and appearance of the corresponding cleaved bands in mice.
CAS Number
93793-83-0
Product Name Alternative
HOE 760 | TZU-0460
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 12 mg/mL (31.17 mM) ; Water: 77 mg/mL (200.05 mM) ; DMSO: 77 mg/mL (200.05 mM)
Smiles
CC (=O) OCC (=O) NCCCOC1=CC=CC (=C1) CN2CCCCC2.Cl
Molecular Formula
C19H29ClN2O4
Molecular Weight
384.9
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[2-oxo-2-[3-[3- (piperidin-1-ylmethyl) phenoxy]propylamino]ethyl] acetate; hydrochloride

Chemical Information

Roxatidine Acetate Hydrochloride

Roxatidine acetate hydrochloride is a member of piperidines. It contains a Roxane.

CAS Number93793-83-0
PubChem CID56704
IUPAC Name[2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride
Molecular FormulaC19H29ClN2O4
Molecular Weight384.9
Topological Polar Surface Area67.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Heavy Atom Count26
Formal Charge0
Complexity410
SMILES
CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
InChI
InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
InChIKey
FEWCTJHCXOHWNL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Roxatidine Acetate Hydrochloride
CAS: 93793-83-0
CID: 56704
Formula: C19H29ClN2O4
MW: 384.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass384.1815851
Monoisotopic Mass384.1815851
Topological Polar Surface Area67.9 Ų
Heavy Atom Count26
Formal Charge0
Complexity410
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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