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RG7112

CAT: 0013-GTR19160717-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160717-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective inhibitor of p53-MDM2 interaction; binds MDM2 with high affinity (Kd=11 nM) ; stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts. orally bioactive. (In Vitro) :RG7112 (0-5 μM) stabilizes wild-type p53 and induces p53 signaling in cancer cells. RG7112 effectively activates p53 functions in cancer cells. (In Vivo) :RG7112 (25-200 mg/kg, single oral dose) activates p53 pathway and induces apoptosis in tumor cells in vivo.RG7112 (100 mg/kg, gavage once per day, 5 days/week for 3 weeks) reduces tumor growth rate and increases survival in GBM models.
CAS Number
939981-39-2
Product Name Alternative
RG-7112 | RG 7112
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCOC1=C (C=CC (=C1) C (C) (C) C) C2=NC (C (N2C (=O) N3CCN (CC3) CCCS (=O) (=O) C) (C) C4=CC=C (C=C4) Cl) (C) C5=CC=C (C=C5) Cl
Molecular Formula
C38H48Cl2N4O4S
Molecular Weight
727.7831
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Methanone, [ (4S,5R) -4,5-bis (4-chlorophenyl) -2-[4- (1,1-dimethylethyl) -2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3- (methylsulfonyl) propyl]-1-piperazinyl]-

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Alternative Products

CatalogName
MBS131293RG7112
A11523-50RG7112 50mg
A11523-100RG7112 100mg
A11523-500RG7112 500mg
A11523-25RG7112 25mg
A11523-10RG7112 10mg
A11523-5RG7112 5mg
A11523-2RG7112 2mg
A11523-1RG7112 1mg
A11523-10mM-DRG7112 10mM * 1mL in DMSO

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