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AMG-900

CAT: 0013-GTR19160687-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160687-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively; displays excellent specificity in a panel of 26 kinases with exception of p38α and TYK2 (IC50=53 and 220 nM), also exhibits high affinity (Kd< 50 nM) with DDR1, DDR2, and LTK receptor tyrosine kinases; blocks the proliferation of multiple human tumor cell lines including cell lines resistant to paclitaxel, AZD1152, MK-0457, and PHA-739358 with IC50 of 0.7-5.3 nM; blocks the phosphorylation of histone H3 in a dose-dependent manner and significantly inhibits the growth of HCT116 tumor xenografts.Blood Cancer Phase 1 Clinical.
CAS Number
945595-80-2
Product Name Alternative
AMG 900 | AMG900
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=CSC (C2=NN=C (NC3=CC=C (OC4=NC=CC=C4C5=NC (N) =NC=C5) C=C3) C6=C2C=CC=C6) =C1
Molecular Formula
C28H21N7OS
Molecular Weight
503.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Phthalazinamine, N-[4-[[3- (2-amino-4-pyrimidinyl) -2-pyridinyl]oxy]phenyl]-4- (4-methyl-2-thienyl) -

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