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MK-8998

CAT: 0013-GTR19160661-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160661-02Size:500 mg
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Description
MK-8998 (CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia.; does not block D2, 5HT2a, muscarinic, or histaminic receptors; has the potential for a substantially improved side effect profile compared with currently available atypical antipsychotics.Schizophrenia Phase 2 Clinical.
CAS Number
953778-58-0
Product Name Alternative
CX-8998
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) C1=CC=C (CC (N[C@H] (C) C2=NC=C (OCC (F) (F) F) C=C2) =O) C=C1
Molecular Formula
C20H23F3N2O2
Molecular Weight
380.4040296
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, 4- (1-methylethyl) -N-[ (1R) -1-[5- (2,2,2-trifluoroethoxy) -2-pyridinyl]ethyl]-

Chemical Information

Suvecaltamide

Suvecaltamide is under investigation in clinical trial NCT05122650 (A Study to Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)).

CAS Number953778-58-0
PubChem CID24765479
IUPAC Name2-(4-propan-2-ylphenyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]acetamide
Molecular FormulaC20H23F3N2O2
Molecular Weight380.4
XLogP4.2
Topological Polar Surface Area51.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity463
SMILES
C[C@H](C1=NC=C(C=C1)OCC(F)(F)F)NC(=O)CC2=CC=C(C=C2)C(C)C
InChI
InChI=1S/C20H23F3N2O2/c1-13(2)16-6-4-15(5-7-16)10-19(26)25-14(3)18-9-8-17(11-24-18)27-12-20(21,22)23/h4-9,11,13-14H,10,12H2,1-3H3,(H,25,26)/t14-/m1/s1
InChIKey
IQIKXZMPPBEWAD-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of Suvecaltamide
CAS: 953778-58-0
CID: 24765479
Formula: C20H23F3N2O2
MW: 380.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.4
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass380.17116247
Monoisotopic Mass380.17116247
Topological Polar Surface Area51.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity463
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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B3212-5MK-8998
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