Products for Research Use Only
RegisterLogin

GSK1059615

CAT: 0013-GTR19160648-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160648-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively; inhibits survival and proliferation of established (SCC-9, SQ20B and A253 lines) and primary human HNSCC cells, blocks PI3K-AKT-mTOR activation in HNSCC cells, induces programmed necrosis but not apoptosis, suppresses SCC-9 tumor growth in nude mice; strongly reduces neutrophil-sperm interaction with IC50 of <10 nM in cattle.Solid Tumors Phase 1 Discontinued (In Vitro) :GSK1059615 inhibits PI3Kα, β, γ and δ, with Ki of 0.42 nM, 0.6 nM, 0.47 nM and 1.7 nM, respectively. In T47D and BT474 cancer cells, GSK1059615 inhibits the phosphorylation of Akt at S473, with IC50 of 40 nM. (In Vivo) :GSK1059615 (25 mg/kg) effectively inhibits tumor growth in xenograft mice models of BT474 or HCC1954 breast cancer cells.
CAS Number
958852-01-2
Product Name Alternative
GSK 1059615 | GSK-1059615
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1cc2c (cc1/C=C\3/C (=O) NC (=O) S3) c (ccn2) c4ccncc4
Molecular Formula
C18H11N3O2S
Molecular Weight
333.3638
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Thiazolidinedione, 5-[[4- (4-pyridinyl) -6-quinolinyl]methylene]-, (5Z) -

Related Products

CatalogName
GTR19205718-01GSK1059865

Alternative Products

CatalogName
B2176-25GSK1059615
A10438-100GSK1059615 100mg
A10438-2GSK1059615 2mg
A10438-50GSK1059615 50mg
A10438-25GSK1059615 25mg
A10438-10GSK1059615 10mg
A10438-5GSK1059615 5mg

Popular Products