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Pyrazinamide

CAT: 0013-GTR19160600-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160600-01Size:1 g
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Description
Pyrazinamide (Pyrazinoic acid amide) is an agent used to treat tuberculosis. M. tuberculosis has the enzyme pyrazinamidase which is only active in acidic conditions. Pyrazinamidase converts pyrazinamide (Pyrazinoic acid amide) to the active form, pyrazinoic acid which accumulates in the bacilli. Pyrazinoic acid inhibits the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. (In Vitro) :Pyrazinamide exhibits remarkable activity in vivo activity, has no activity against growing Mycobacterium tuberculosis except at an acidic pH. In M. tuberculosis, acidic pH enhances the intracellular accumulation of pyrazinoic acid (POA), the active derivative of PZA.POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis.
CAS Number
98-96-4
Product Name Alternative
Aldinamide | a-Pyrazinamide | MK 56 | Pyrazinecarboxamide | Pyrazinoic Acid Amide | NSC 14911
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 2 mg/mL (16.24 mM) ; Water: 12 mg/mL (97.47 mM) ; DMSO: 25 mg/mL (203.07 mM)
Smiles
O=C (C1=NC=CN=C1) N
Molecular Formula
C5H5N3O
Molecular Weight
123.11
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Pyrazinecarboxamide

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