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Droxinostat

CAT: 0013-GTR19160587-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160587-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively; does not inhibit HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10 with IC50 of >20 uM; sensitizes malignant cells to death receptor ligands FAS and TRAIL sensitization with IC50 of 20 and 39 uM, respectively; decreases the expression of the caspase-8 inhibitor FLIP, downregulates c-FLIP (L) and c-FLIP (S) mRNA and protein levels, causes PARP degradation, reduces cell survival, and induces apoptosis in MCF-7 breast cancer cells.
CAS Number
99873-43-5
Product Name Alternative
NS 41080 | NS-41080 | NS41080
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NO) CCCOC1=CC=C (Cl) C=C1C
Molecular Formula
C11H14ClNO3
Molecular Weight
243.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Butanamide, 4- (4-chloro-2-methylphenoxy) -N-hydroxy-

Alternative Products

CatalogName
A4100-10Droxinostat

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