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Uprosertib

CAT: 0013-GTR19160572-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160572-02Size:500 mg
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Description
Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
CAS Number
1047634-65-0
Product Name Alternative
GSK2141795, GSK 795, Uprosertib
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL
Smiles
Cn1c (c (cn1) Cl) c1c (oc (c1) C (=O) N[C@@H] (Cc1cc (c (cc1) F) F) CN) Cl
Molecular Formula
C18H16Cl2F2N4O2
Molecular Weight
429.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- ((S) -1-amino-3- (3,4-difluorophenyl) propan-2-yl) -5-chloro-4- (4-chloro-1-methyl-1H-pyrazol-5-yl) furan-2-carboxamide

Chemical Information

Uprosertib

Uprosertib has been used in trials studying the treatment of Cancer, Melanoma, Solid Tumours, Cervical Cancer, and HER2/Neu Negative, among others.

CAS Number1047634-65-0
PubChem CID51042438
IUPAC NameN-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-1-methylpyrazol-5-yl)furan-2-carboxamide
Molecular FormulaC18H16Cl2F2N4O2
Molecular Weight429.2
XLogP3.4
Topological Polar Surface Area86.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity550
SMILES
CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)N[C@@H](CC3=CC(=C(C=C3)F)F)CN)Cl
InChI
InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
InChIKey
AXTAPYRUEKNRBA-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of Uprosertib
CAS: 1047634-65-0
CID: 51042438
Formula: C18H16Cl2F2N4O2
MW: 429.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.2
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass428.0618375
Monoisotopic Mass428.0618375
Topological Polar Surface Area86.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity550
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FU103960-01Uprosertib
T15428-01Uprosertib hydrochloride
C12726-5mgUprosertib (GSK2141795)
CS-T-103805Uprosertib-13C4d3
MBS384825-01GSK2141795 (Uprosertib, GSK795)
A15809-1GSK2141795 (Uprosertib, GSK795) 1mg
A15809-200GSK2141795 (Uprosertib, GSK795) 200mg
A15809-50GSK2141795 (Uprosertib, GSK795) 50mg
A15809-100GSK2141795 (Uprosertib, GSK795) 100mg
A15809-2GSK2141795 (Uprosertib, GSK795) 2mg

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