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AC1NS4RE

CAT: 0013-GTR19160565-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160565-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X (L) and p21.
CAS Number
1055412-47-9
Product Name Alternative
SU5614 | SU 5614 | SU5614
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 16.67 mg/mL (61.12 mM)
Smiles
Cc1cc (c ([nH]1) /C=C\1/c2c (ccc (c2) Cl) NC1=O) C
Molecular Formula
C15H13ClN2O
Molecular Weight
272.73
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3Z) -5-Chloro-3-[ (3,5-dimethyl-1H-pyrrol-2-yl) methylene]-1,3-dihydro-2H-indol-2-one

Alternative Products

CatalogName
MBS3607123-01AC1NS4RE

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