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RK-33

CAT: 0013-GTR19160560-07Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160560-07Size:25 mg
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Description
RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
CAS Number
1070773-09-9
Product Name Alternative
RK-33 | RK 33 | RK33.
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (116.70 mM)
Smiles
COC1=CC=C (C=C1) CN2C=NC3=C2N=CN=C4C3=NC (=O) N4CC5=CC=C (C=C5) OC
Molecular Formula
C23H20N6O3
Molecular Weight
428.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,7-dihydro-3,7-bis[ (4-methoxyphenyl) methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

Chemical Information

3,7-dihydro-3,7-bis((4-methoxyphenyl)methyl)-2H-diimidazo(4,5-d:4',5'-f)(1,3)diazepin-2-one

inhibits DDX3 RNA helicase

CAS Number1070773-09-9
PubChem CID46184988
IUPAC Name5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one
Molecular FormulaC23H20N6O3
Molecular Weight428.4
XLogP2.6
Topological Polar Surface Area93.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity783
SMILES
COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
InChI
InChI=1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
InChIKey
COUMZXFUZDBRCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3,7-dihydro-3,7-bis((4-methoxyphenyl)methyl)-2H-diimidazo(4,5-d:4',5'-f)(1,3)diazepin-2-one
CAS: 1070773-09-9
CID: 46184988
Formula: C23H20N6O3
MW: 428.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.4
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass428.15968852
Monoisotopic Mass428.15968852
Topological Polar Surface Area93.7 Ų
Heavy Atom Count32
Formal Charge0
Complexity783
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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TRC-R545500-25MGRK 33

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