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LDC000067

CAT: 0013-GTR19160557-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160557-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDC000067 is a potent and selective CDK9 inhibitor. LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis. Analysis of de novo RNA synthesis suggested a wide ranging positive role of CDK9. At the molecular and cellular level, LDC000067 reproduced effects characteristic of CDK9 inhibition such as enhanced pausing of RNA polymerase II on genes and, most importantly, induction of apoptosis in cancer cells.
CAS Number
1073485-20-7
Product Name Alternative
LDC000067 | LDC-000067 | LDC 000067
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 47 mg/mL 126.88 mM
Smiles
COc1ccccc1c1cc (ncn1) Nc1cccc (c1) CS (=O) (=O) N
Molecular Formula
C18H18N4O3S
Molecular Weight
370.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- (6- (1-Methyl-1H-pyrazol-4-yl) -[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio) quinoline

Alternative Products

CatalogName
B4754-10LDC000067
A14273-25LDC000067 25mg
A14273-2LDC000067 2mg
A14273-5LDC000067 5mg
A14273-10LDC000067 10mg
A14273-100LDC000067 100mg
A14273-50LDC000067 50mg
MBS130601-01LDC000067(LDC-067)

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