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Cilomilast

CAT: 0013-GTR19169923-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169923-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cilomilast (SB-207499) is a selective PDE4 inhibitor with an IC50 of approximately 110 nM, exhibiting potent anti-inflammatory effects with minimal CNS penetration. It has been investigated in clinical Phase 3 trials for chronic obstructive pulmonary disease (COPD) and studied in models of inflammatory cell activation.
CAS Number
153259-65-5
Product Name Alternative
COPD, chronic, Cilomilast, disease, anti-inflammatory, Ariflo, asthma, HPDE4, obstructive, LPDE4, PDE4, immunomodulatory, Inhibitor, inhibit, phosphodiesterase, Phosphodiesterase, Phosphodiesterase (PDE), SB 207499, SB207499, SB-207499, pulmonary
Field of Research
Metabolism Research
Purity
97.37% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:60 mg/mL (174.71 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.82 mM) ; Ethanol:31 mg/mL (90.27 mM)
Smiles
COc1ccc (cc1OC1CCCC1) [C@]1 (CC[C@@H] (CC1) C (O) =O) C#N
Molecular Formula
C20H25NO4
Molecular Weight
343.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cilomilast

4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)-1-cyclohexanecarboxylic acid is a member of methoxybenzenes.

CAS Number153259-65-5
PubChem CID151170
IUPAC Name4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
Molecular FormulaC20H25NO4
Molecular Weight343.4
XLogP3.4
Topological Polar Surface Area79.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity511
SMILES
COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
InChI
InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)
InChIKey
CFBUZOUXXHZCFB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cilomilast
CAS: 153259-65-5
CID: 151170
Formula: C20H25NO4
MW: 343.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.4
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass343.17835828
Monoisotopic Mass343.17835828
Topological Polar Surface Area79.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity511
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
268584-01Cilomilast

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