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Edrophonium chloride

CAT: 0013-GTR19169453-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19169453-01Size:1 ml x 10 mM (in DMSO)
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Description
Edrophonium chloride is a reversible acetylcholinesterase inhibitor that binds to the enzyme's active site, preventing acetylcholine hydrolysis. This small molecule is utilized in research applications, including in vitro enzymatic assays and in vivo studies of neuromuscular function and cholinergic signaling.
CAS Number
116-38-1
Product Name Alternative
Inhibitor, inhibit, AChE, Edrophonium, Edrophonium chloride, Edrophonium Chloride, Cholinesterase (ChE)
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
97.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.92 mM) ; DMSO:31 mg/mL (153.7 mM)
Smiles
[Cl-].CC[N+] (C) (C) c1cccc (O) c1
Molecular Formula
C10H16ClNO
Molecular Weight
201.69
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Edrophonium Chloride

Edrophonium chloride is the chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. It has a role as a diagnostic agent, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote. It is a chloride salt and a quaternary ammonium salt. It contains an edrophonium.

CAS Number116-38-1
PubChem CID8307
IUPAC Nameethyl-(3-hydroxyphenyl)-dimethylazanium chloride
Molecular FormulaC10H16ClNO
Molecular Weight201.69
Topological Polar Surface Area20.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count13
Formal Charge0
Complexity145
SMILES
CC[N+](C)(C)C1=CC(=CC=C1)O.[Cl-]
InChI
InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
InChIKey
BXKDSDJJOVIHMX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Edrophonium Chloride
CAS: 116-38-1
CID: 8307
Formula: C10H16ClNO
MW: 201.69
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight201.69
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass201.0920418
Monoisotopic Mass201.0920418
Topological Polar Surface Area20.2 Ų
Heavy Atom Count13
Formal Charge0
Complexity145
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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