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FM-381

CAT: 0013-GTR19168652-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168652-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FM381 is a highly potent and selective covalent reversible inhibitor of JAK3, exhibiting an IC50 of 127 pM. It demonstrates over 400-fold selectivity against JAK1, JAK2, and TYK2. This inhibitor is a valuable chemical tool for probing JAK3-dependent signaling in both cellular and in vivo models of immunology and oncology research.
CAS Number
2226521-65-7
Product Name Alternative
Inhibit, JAK, Janus kinase, JAK3, Inhibitor, FM381, FM-381, FM 381
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.71% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:12.5 mg/mL (29.17 mM)
Smiles
CN (C) C (=O) C (=C\c1ccc (o1) -c1nc2cnc3[nH]ccc3c2n1C1CCCCC1) \C#N
Molecular Formula
C24H24N6O2
Molecular Weight
428.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(E/Z)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
CAS Number2226521-65-7
PubChem CID122197584
IUPAC Name(E)-2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide
Molecular FormulaC24H24N6O2
Molecular Weight428.5
XLogP3.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count32
Formal Charge0
Complexity785
SMILES
CN(C)C(=O)/C(=C/C1=CC=C(O1)C2=NC3=CN=C4C(=C3N2C5CCCCC5)C=CN4)/C#N
InChI
InChI=1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27)/b15-12+
InChIKey
GJMZWYLOARVASY-NTCAYCPXSA-N
Chemical Structure
2D Structure
2D structure of (E/Z)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
CAS: 2226521-65-7
CID: 122197584
Formula: C24H24N6O2
MW: 428.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.5
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass428.19607403
Monoisotopic Mass428.19607403
Topological Polar Surface Area104 Ų
Heavy Atom Count32
Formal Charge0
Complexity785
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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