Products for Research Use Only

FM-381

CAT: 0013-GTR19168652-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168652-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FM381 is a highly potent and selective covalent reversible inhibitor of JAK3, exhibiting an IC50 of 127 pM. It demonstrates over 400-fold selectivity against JAK1, JAK2, and TYK2. This inhibitor is a valuable chemical tool for probing JAK3-dependent signaling in both cellular and in vivo models of immunology and oncology research.
CAS Number
2226521-65-7
Product Name Alternative
Inhibit, JAK, Janus kinase, JAK3, Inhibitor, FM381, FM-381, FM 381
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.71% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:12.5 mg/mL (29.17 mM)
Smiles
CN (C) C (=O) C (=C\c1ccc (o1) -c1nc2cnc3[nH]ccc3c2n1C1CCCCC1) \C#N
Molecular Formula
C24H24N6O2
Molecular Weight
428.49
Storage Conditions
-20°C
Notes
For research use only.

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