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PI-1840

CAT: 0013-GTR19167936-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19167936-01Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI-1840 is a potent, reversible, and selective inhibitor of the proteasome's chymotrypsin-like (CT-L) activity (IC50 = 27 nM), exhibiting minimal effect on trypsin-like and postglutamyl-peptide-hydrolysis-like activities. This compound is a valuable research tool for studying proteasome function in cellular models and has been utilized in investigations of cancer and neurodegenerative disease pathways.
CAS Number
1401223-22-0
Product Name Alternative
Cell proliferation, cell cycle, Chymotrypsin-like proteasome, Bcl-2 Family, Caspase, Autophagy, anticancer, Apoptosis, Inhibitor, inhibit, MG-63 cells, PARP, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, poly ADP ribose polymerase, PI1840, PI-1840, PI 1840, Proteasome, proteasome substrates, U2-OS cells
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction
Purity
98.82% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.07 mM) ; Ethanol:31 mg/mL (78.59 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:72 mg/mL (182.52 mM)
Smiles
CCCc1ccc (OCC (=O) N (Cc2nc (no2) -c2cccnc2) C (C) C) cc1
Molecular Formula
C22H26N4O3
Molecular Weight
394.47
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

CatalogName
BGC22322-01PI-1840
462588-01PI 1840
A14146-100PI-1840 100mg
A14146-50PI-1840 50mg
A14146-10PI-1840 10mg
A14146-200PI-1840 200mg
A14146-5PI-1840 5mg
A14146-25PI-1840 25mg
bs-75564C-01PI-1840 [Proteasome Inhibitor]

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