Products for Research Use Only
RegisterLogin

Navoximod

CAT: 0013-GTR19166318-07Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19166318-07Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Navoximod (GDC-0919) is a potent small molecule inhibitor of the indoleamine 2,3-dioxygenase (IDO) pathway, exhibiting a Ki of 7 nM and an EC50 of 75 nM. It has been utilized in both in vitro and in vivo research to investigate immunomodulation, particularly in the fields of oncology and autoimmune disease.
CAS Number
1402837-78-8
Product Name Alternative
Indoleamine 2,3-Dioxygenase, Indoleamine 2,3Dioxygenase (IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, inhibit, Indoleamine2,3Dioxygenase (IDO), Navoximod, NLG 919, NLG-​919, NLG-?919, NLG919, NLG-919, Inhibitor, GDC 0919, GDC0919, GDC-0919, IDO
Field of Research
Metabolism Research
Purity
99.37% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.64 mM) ; DMSO:100 mg/mL (316.09 mM)
Smiles
[H][C@@]1 (CC[C@H] (O) CC1) [C@H] (O) C[C@H]1c2c (cccc2F) -c2cncn12
Molecular Formula
C18H21FN2O2
Molecular Weight
316.37
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

trans-4-((1R)-2-((5S)-6-Fluoro-5H-imidazo(5,1-a)isoindol-5-yl)-1-hydroxyethyl)cyclohexanol

Navoximod is under investigation in clinical trial NCT02048709 (Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Advanced Solid Tumors).

CAS Number1402837-78-8
PubChem CID70914230
IUPAC Name4-[(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol
Molecular FormulaC18H21FN2O2
Molecular Weight316.4
XLogP2.1
Topological Polar Surface Area58.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity416
SMILES
C1CC(CCC1[C@@H](C[C@H]2C3=C(C=CC=C3F)C4=CN=CN24)O)O
InChI
InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11?,12?,15-,17+/m0/s1
InChIKey
YGACXVRLDHEXKY-LHPNLFKDSA-N
Chemical Structure
2D Structure
2D structure of trans-4-((1R)-2-((5S)-6-Fluoro-5H-imidazo(5,1-a)isoindol-5-yl)-1-hydroxyethyl)cyclohexanol
CAS: 1402837-78-8
CID: 70914230
Formula: C18H21FN2O2
MW: 316.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight316.4
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass316.15870608
Monoisotopic Mass316.15870608
Topological Polar Surface Area58.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity416
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-18770B-01Navoximod
MBS5812731Navoximod phosphate
327017Navoximod free base
A22549-100Navoximod free base 100mg
A22549-25Navoximod free base 25mg
A22549-50Navoximod free base 50mg
A22549-5Navoximod free base 5mg
A22549-10Navoximod free base 10mg
A22549-1Navoximod free base 1mg
A22549-10mM-DNavoximod free base 10mM * 1mL in DMSO

Popular Products