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Exatecan Mesylate

CAT: 0013-GTR19166306-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166306-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exatecan Mesylate (DX-8951f) is a potent inhibitor of DNA topoisomerase I, exhibiting an IC50 of 2.2 μM. This camptothecin analog has demonstrated antitumor activity in both in vitro cytotoxicity assays and in vivo xenograft models, supporting its research use in oncology and cancer pharmacology.
CAS Number
169869-90-3
Product Name Alternative
DX8951f, ADC Cytotoxin, ADCCytotoxin, Exatecan, Exatecan Mesylate, Inhibitor, inhibit, Topoisomerase, Topo I
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Purity
97.32% (May vary between batches)
Solubility
H2O:6 mg/mL (11.29 mM) ; DMSO:8 mg/mL (15.05 mM)
Smiles
CS (O) (=O) =O.CC[C@@]1 (O) C (=O) OCc2c1cc1-c3nc4cc (F) c (C) c5CC[C@H] (N) c (c3Cn1c2=O) c45
Molecular Formula
C25H26FN3O7S
Molecular Weight
531.55
Storage Conditions
Keep away from direct sunlight, store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

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