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MRTX1133

CAT: 0013-GTR19165627-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165627-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRTX1133 is a potent, selective, and non-covalent small-molecule inhibitor targeting the KRAS G12D mutant with sub-picomolar affinity (K_D = 0.2 pM) . It demonstrates antitumor efficacy in G12D-mutated cell lines and in vivo models, showing selectivity over wild-type KRAS, making it a valuable research tool for oncology and targeted therapy studies.
CAS Number
2621928-55-8
Product Name Alternative
Active, cells, Inhibitor, ERK, G12D, mutant, MRTX1133, MRTX-1133, MRTX 1133, inactive, KRAS G12D, KRAS, inhibit, tumor, states, Ras, phosphorylation, wild-type
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
96.84% (May vary between batches)
Solubility
DMSO: 50 mg/mL (83.25 mM), Sonication is recommended
Smiles
C (OC=1N=C (C2=C (N1) C (F) =C (N=C2) C=3C4=C (C=C (O) C3) C=CC (F) =C4C#C) N5CC6NC (C5) CC6) [C@@]78N (C[C@H] (F) C7) CCC8
Molecular Formula
C33H31F3N6O2
Molecular Weight
600.63
References & Citations
Elodie Roger et al. ATM Deficiency Induces TGF-β-Mediated Stromal Programming in Pancreatic Cancer Cancer Res, (2026)
Pubmed id
42113576
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-134813-01MRTX1133
HY-134813AMRTX1133 (formic)
MBS5798095MRTX1133 formic
A24519-10MRTX1133 10mg
A24519-5MRTX1133 5mg
A24519-1MRTX1133 1mg
A24519-50MRTX1133 50mg

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