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Vorasidenib

CAT: 0804-HY-104042-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-104042-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D) -2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K. Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation[1][2].
CAS Number
1644545-52-7
Product Name Alternative
AG-881
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Vorasidenib.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F
Molecular Formula
C14H13ClF6N6
Molecular Weight
414.74
Precautions
H302, H315, H319, H335
References & Citations
[1]Fujii T, et al. Targeting isocitrate dehydrogenase (IDH) in cancer. Discov Med. 2016 May;21 (117) :373-80.|[2]Ma T, et al. Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2) : An Update and Perspective. J Med Chem. 2018 Oct 25;61 (20) :8981-9003.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
IDH1; IDH2

Alternative Products

CatalogName
BA7847-5.1Vorasidenib
A16908-25Vorasidenib 25mg
A16908-5Vorasidenib 5mg
A16908-1Vorasidenib 1mg
CS-O-61472Vorasidenib-d3
A16908-100Vorasidenib 100mg
A16908-50Vorasidenib 50mg
A16908-2Vorasidenib 2mg
A16908-10Vorasidenib 10mg
C13538-01Vorasidenib (AG-881)

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