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CX-6258

CAT: 0013-GTR19164318-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164318-02Size:1 g
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Description
A potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively; exhibits in vitro synergy with chemotherapeutics and robust in vivo efficacy in driven tumor models; also decreases steady state levels and half-life of NKX3.1 protein but not mRNA in prostate cancer cells.Blood Cancer Discontinued.
CAS Number
1202916-90-2
Product Name Alternative
CX6258 | CX 6258
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CN1CCCN (CC1) C (=O) C2=CC=CC (=C2) C3=CC=C (O3) /C=C/4\C5=C (C=CC (=C5) Cl) NC4=O
Molecular Formula
C26H24ClN3O3
Molecular Weight
461.9401
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indol-2-one, 5-chloro-3-[[5-[3-[ (hexahydro-4-methyl-1H-1,4-diazepin-1-yl) carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, (3E) -

Chemical Information

CX-6258

CX-6258 is an organic molecular entity.

CAS Number1202916-90-2
PubChem CID44545852
IUPAC Name(3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one
Molecular FormulaC26H24ClN3O3
Molecular Weight461.9
XLogP3.9
Topological Polar Surface Area65.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count33
Formal Charge0
Complexity774
SMILES
CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O
InChI
InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+
InChIKey
KGBPLKOPSFDBOX-CJLVFECKSA-N
Chemical Structure
2D Structure
2D structure of CX-6258
CAS: 1202916-90-2
CID: 44545852
Formula: C26H24ClN3O3
MW: 461.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.9
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass461.1506193
Monoisotopic Mass461.1506193
Topological Polar Surface Area65.8 Ų
Heavy Atom Count33
Formal Charge0
Complexity774
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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