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Verteporfin

CAT: 0013-GTR19163912-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163912-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Verteporfin (CL 318952; Visudyne), a benzoporphyrin derivative monoacid ring A, is a photosensitising drug for photodynamic therapy (PDT) activated by low-intensity, nonheat-generating light of 689nm wavelength. (In Vitro) :Verteporfin is specifically selected by PDX-cell screening. The concentrations to cause 50% growth inhibition (GI50) for PhLO, PhLH, and PhLK are 228 nM, 395 nM, and 538 nM, respectively, whereas GI50 for ALL-1, TCC-Y/sr, and NPhA1 are 3.93 μM, 2.11 μM, and 5.61 μM, respectively. GSH significantly reduces the sensitivity of 2 out of 3 PDX cells to verteporfin. Verteporfin reduces the mitochondrial membrane potential in PDX cells. Verteporfin reduces the PTX-resistance on HCT-8/T cells by inhibiting YAP expression and combination therapy with verteporfin and NSC 125973 shows synergism on inhibition of YAP and cytotoxicity to HCT-8/T. (In Vivo) :Verteporfin (10 mg/kg, c.s.c.) and BMS-354825 significantly reduces the leukemia cell ratio, and combined therapy further reduced the number of leukemia cells in the spleen.
CAS Number
129497-78-5
Product Name Alternative
BPD-MA | CL 318,952
Purity
>98% (HPLC)
Solubility
DMSO: 100 mg/mL (139.12 mM)
Smiles
O=C (O) CCC1=C (C) C (/C=C2C (C=C) =C (C) /C (N/2) =C/3) =N/C1=C\C (N4) =C (CCC (OC) =O) C (C) =C4/C=C5[C@]6 (C) [C@H] (C (OC) =O) C (C (OC) =O) =CC=C6C3=N/5.
Molecular Formula
C41H42N4O8
Molecular Weight
718.79
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1) : 3-[ (23S,24R) -14-ethenyl-5- (3-methoxy-3-oxopropyl) -22,23-bis (methoxycarbonyl) -4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11 (27),12,14,16,18 (25),19,21-dodecaen-9-yl]propanoic acid.

Alternative Products

CatalogName
A8327-25Verteporfin

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