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Quetiapin

CAT: 0013-GTR19163639-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163639-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor. (In Vitro) :Quetiapine (<100 μM; 24 hours) has no significant effect on cell viabilities.Quetiapine (10 μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner.Quetiapine (10 μM) also inhibits TNF-α synthesis. (In Vivo) :Quetiapine (10 mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ) -induced chronic mouse model of demyelination.
CAS Number
111974-69-7
Purity
>98% (HPLC)
Solubility
DMSO: 36 mg/mL; Water: <1 mg/mL
Smiles
OCCOCCN1CCN (CC1) C1=NC2=CC=CC=C2SC2=CC=CC=C12
Molecular Formula
C21H25N3O2S
Molecular Weight
383.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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