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HLCL-61 hydrochloride

CAT: 0013-GTR19163566-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163566-01Size:1 g
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Description
A novel potent and selective protein arginine methyltransferase PRMT5 inhibitor; shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members; exhibits effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, significantly increases expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML cells; inhibits the proliferation of AML cell lines and primary blasts with IC50 of 7.21-21.46 uM.
CAS Number
1158279-20-9
Product Name Alternative
HLCL61 hydrochloride | HLCL 61 hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
CCN1C2=C (C=C (C=C2) CNCC3=CC=CC=C3OC) C4=CC=CC=C41.Cl
Molecular Formula
C23H25ClN2O
Molecular Weight
380.9104
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
9H-Carbazole-3-methanamine, 9-ethyl-N-[ (2-methoxyphenyl) methyl]-, hydrochloride (1:1)

Chemical Information

HLCL-61 hydrochloride
CAS Number1158279-20-9
PubChem CID17208222
IUPAC Name1-(9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine;hydrochloride
Molecular FormulaC23H25ClN2O
Molecular Weight380.9
Topological Polar Surface Area26.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity442
SMILES
CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
InChI
InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
InChIKey
XYAVCNMZZKTEGR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of HLCL-61 hydrochloride
CAS: 1158279-20-9
CID: 17208222
Formula: C23H25ClN2O
MW: 380.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass380.1655411
Monoisotopic Mass380.1655411
Topological Polar Surface Area26.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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HY-100025A-01HLCL-61 (hydrochloride)
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Fr13123L-01[4- (Tetrahydropyran-4-yloxy) phenyl]methylamine hydrochloride (864266-61-5 Free base)
MBS6118677-01Bay 61-3606 Hydrochloride (2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl)
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