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Oxcarbazepine

CAT: 0013-GTR19162726-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162726-01Size:1 g
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Description
Oxcarbazepine is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat partial seizures in epileptic children and adults. (In Vitro) :Oxcarbazepine significantly inhibits glioblastoma cell growth and reaches IC50 at therapeutic concentrations. The IC50s of Oxcarbazepine screened with the U87 and T98 cell lines are 12.35 and 9.45 μg/mL, respectively. (In Vivo) :Oxcarbazepine protectes mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o. No tolerance toward this anticonvulsant effect is observed when rats are treated with Oxcarbazepine daily for 4 weeks.
CAS Number
28721-07-5
Product Name Alternative
GP47680
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 7 mg/mL (27.74 mM)
Smiles
O=C (C1=CC2=CC=CCC2=[N+] ([O-]) C3=CC=CC=C13) N
Molecular Formula
C15H12N2O2
Molecular Weight
252.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide

Alternative Products

CatalogName
B2279-10Oxcarbazepine

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