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Dapivirine

CAT: 0013-GTR19162516-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162516-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. (In Vitro) :Dapivirine (4-64 μM, 24, 48, 72, 96 and 120 hours) inhibits proliferation of glioma cells and induces apoptosis (16 μM, 12-48 h) .Dapivirine (8 and 16 μM, 12 h) enhances invasion of glioma cells.Dapivirine (16 μM, 12 h, 24 h and 48 h) promotes autophagy in U87 cells.Dapivirine (TMC120-R147681) apparently blocks infection in the primary cultures at a 10 nM concentration, but secondary cultures revealed that a 100 nM concentration was needed to completely prevent proviral integration. (In Vivo) :Dapivirine (16 mg/kg, once every 3 days for 12 days) exhibits potent antitumor activity in human glioblastoma models in mice.Dapivirine has been shown to have a half-life in the range of 65 to 90 h.
CAS Number
244767-67-7
Product Name Alternative
TMC120
Purity
>98% (HPLC)
Solubility
DMSO: 34 mg/mL (103.21 mM)
Smiles
N#CC1=CC=C (NC2=NC=CC (NC3=C (C) C=C (C) C=C3C) =N2) C=C1
Molecular Formula
C20H19N5
Molecular Weight
329.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[[4-[ (2,4,6-Trimethylphenyl) amino]-2-pyrimidinyl]amino]benzonitrile

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