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OSI-930

CAT: 0013-GTR19161639-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161639-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15 nM and 9 nM, respectively; also inhibits Lck, c-Raf, Flt1, and CSF-1R (IC50<100 nM) ; exhibits antitumor activity in mutant Kit-expressing HMC-1 xenograft model.Solid Tumors Phase 1 Discontinued (In Vitro) :OSI-930 inhibits cell proliferation in the HMC-1 cell line with IC50 of 14 nM but has no significant effect on the growth of COLO-205 cell line that does not express constitutively active mutant receptor tyrosine kinase. OSI-930 induces apoptosis in HMC-1 cell line with an EC50 value of 34 nM. OSI-930 inactivates purified, recombinant cytochrome P450 3A4 with a Ki of 24 μM in a time- and concentration-dependent manner. (In Vivo) :OSI-930 (oral gavage; once a day; 38 days; 200 mg/kg) exhibits potent antitumor activity in a broad range of preclinical xenograft models.
CAS Number
728033-96-3
Product Name Alternative
OSI 930 | OSI930
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C1=C (NCC2=CC=NC3=CC=CC=C23) C=CS1) NC4=CC=C (OC (F) (F) F) C=C4
Molecular Formula
C22H16F3N3O2S
Molecular Weight
443.4416
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Thiophenecarboxamide, 3-[ (4-quinolinylmethyl) amino]-N-[4- (trifluoromethoxy) phenyl]-

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