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Benvitimod

CAT: 0013-GTR19161991-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19161991-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A natural aryl hydrocarbon receptor (AhR) agonist with anti-inflammatory properties; binds and activates AhR in multiple cell types, moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes; shows no impact on imiquimod-induced skin inflammation in AhR-deficient mice.Psoriasis Phase 3 Clinical (In Vitro) :Tapinarof activates the AhR pathway through direct binding. Tapinarof dose-dependently induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) (EC50=0.16 nM) . (In Vivo) :Tapinarof acts through AhR to reduce inflammation in IMQ-treated mice. AhR-sufficient mice on a C57Bl/6 background exhibit a reduced clinical score after treatment with Tapinarof or 6-formylindolo (3,2-b) carbazole (FICZ) . In contrast, AhR KO mice do not respond to the anti-inflammatory effects of Tapinarof. FICZ is used as a comparator in these studies and yields similar results, with dramatically reduced inflammatory responses in wild-type, but not AhR KO mice.
CAS Number
79338-84-4
Product Name Alternative
WBI-1001 | WB-1001 | GSK-2894512 | Tapinarof
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C1=C (O) C=C (C=C1O) /C=C/C2=CC=CC=C2) C
Molecular Formula
C17H18O2
Molecular Weight
254.329
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,5-Dihydroxy-4-isopropylstilbene

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