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Perphenazine

CAT: 0013-GTR19161380-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161380-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor (5-HT2A), Alpha-1A adrenergic receptor (α1A), Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor (H1) with Ki of 5.6, 10, 0.765/0.13, 3.4, and 8 nM. (In Vitro) :Perphenazine (40 μM, 48 h) inhibits cell viability, and induces cell apoptosis mediated by CTSD (Cathepsin D) in L02 cells.Perphenazine (30 μM, 24 h) induces intense lysosome vacuolation, impaired lysosomal membrane, and induces lysosomal membrane permeabilization (LMP), ultimately triggering lysosomal cell death in L02 cells.Perphenazine (10-40 μM, 24 h) inhibits autophagic flux in L02 cells.Perphenazine (1 μM, 24 h) decreases glioblastoma U-87 MG cell migration and invasion. (In Vivo) :Perphenazine (oral gavage, 180 mg/kg, every other day for 21 days) induces liver injury and lysosomal membrane damage in ICR mice.Perphenazine (oral administration, 10 mg/kg, every other day for 6 days) attenuates morphological phenotype in mouse models of Th2-type allergic dermatitis.
CAS Number
58-39-9
Product Name Alternative
NSC 150866 | SCH 3940
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
C1CN (CCN1CCCN2C3=CC=CC=C3SC4=C2C=C (C=C4) Cl) CCO
Molecular Formula
C21H26ClN3OS
Molecular Weight
403.97
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-[4-[3- (2-chlorophenothiazin-10-yl) propyl]piperazin-1-yl]ethanol

Alternative Products

CatalogName
B6157-25000Perphenazine

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