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KU-55933

CAT: 0013-GTR19161355-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161355-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases; inhibits ATM-dependent p53 Ser15 phosphorylation in U2OS osteosarcoma cells with IC50 of 0.3 uM, sensitizes the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin; also suppresses the replication of both wild-type and drug-resistant HIV-1 by sensitizing cells to retrovirus-induced cell death.
CAS Number
587871-26-9
Product Name Alternative
KU 55933 | KU55933
Purity
>98% (HPLC)
Solubility
DMSO: 80 mg/mL (Need ultrasonic)
Smiles
O=C1C=C (N2CCOCC2) OC (C3=C4SC5=C (C=CC=C5) SC4=CC=C3) =C1
Molecular Formula
C21H17NO3S2
Molecular Weight
395.4946
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-Pyran-4-one, 2- (4-morpholinyl) -6- (1-thianthrenyl) -

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Alternative Products

CatalogName
A4605-SKU 55933
T2685-01KU-55933

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