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Verdiperstat

CAT: 0013-GTR19160887-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160887-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO) ; inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued (In Vitro) :Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.
CAS Number
890655-80-8
Product Name Alternative
AZD-3241
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL 592.14 mM
Smiles
O=C (N1) C (NC=C2) =C2N (CCOC (C) C) C1=S
Molecular Formula
C11H15N3O2S
Molecular Weight
253.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[2- (propan-2-yloxy) ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

Alternative Products

CatalogName
BA3441-5.1Verdiperstat
A22041-50Verdiperstat 50mg
A22041-10Verdiperstat 10mg
A22041-5Verdiperstat 5mg
A22041-100Verdiperstat 100mg
A22041-2Verdiperstat (AZD3241) 2mg
A22041-1Verdiperstat (AZD3241) 1mg
A22041-25Verdiperstat (AZD3241) 25mg
A22041-10mM-DVerdiperstat (AZD3241) 10mM * 1mL in DMSO

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