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MPEP

CAT: 0013-GTR19169775-05Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169775-05Size:200 mg
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Description
MPEP is a potent and selective antagonist of the metabotropic glutamate receptor 5 (mGlu5), demonstrating an IC50 of 36 nM. It shows negligible activity at other mGlu receptor subtypes (mGlu1b/2/3/4a/7b/8a/6) . This compound is widely used in neuroscience research to investigate mGlu5 function in vitro and in animal models of neurological disorders.
CAS Number
96206-92-7
Product Name Alternative
MPEP, inhibit, mGluR5, Metabotropic glutamate receptors, mGluR, Inhibitor
Field of Research
Neuroscience
Purity
99.31% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.35 mM) ; Ethanol:37 mg/mL (191.47 mM) ; DMSO:37 mg/mL (191.47 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cl.Cc1cccc (n1) C#Cc1ccccc1
Molecular Formula
C14H11N
Molecular Weight
193.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mpep

2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as an anxiolytic drug and a metabotropic glutamate receptor antagonist. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

CAS Number96206-92-7
PubChem CID3025961
IUPAC Name2-methyl-6-(2-phenylethynyl)pyridine
Molecular FormulaC14H11N
Molecular Weight193.24
XLogP3.3
Topological Polar Surface Area12.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count15
Formal Charge0
Complexity251
SMILES
CC1=NC(=CC=C1)C#CC2=CC=CC=C2
InChI
InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
InChIKey
NEWKHUASLBMWRE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mpep
CAS: 96206-92-7
CID: 3025961
Formula: C14H11N
MW: 193.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight193.24
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass193.089149355
Monoisotopic Mass193.089149355
Topological Polar Surface Area12.9 Ų
Heavy Atom Count15
Formal Charge0
Complexity251
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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