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FRAX597

CAT: 0013-GTR19160735-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160735-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FRAX597 is a potent and selective inhibitor of the p21-activated kinases. FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2) -associated Schwannomas. FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP-competitive Group I PAK inhibitors with significant potential for the treatment of NF2 and other cancers.
CAS Number
1286739-19-2
Product Name Alternative
FRAX597 | FRAX-597 | FRAX 597
Purity
>98% (HPLC)
Solubility
DMSO : 14.29 mg/mL. 25.60 mM; H2O : < 0.1 mg/mL
Smiles
CCn1c2nc (ncc2cc (c1=O) c1c (cc (cc1) c1cncs1) Cl) Nc1ccc (cc1) N1CCN (CC1) C
Molecular Formula
C29H28ClN7OS
Molecular Weight
558.1
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-[2-chloro-4- (1,3-thiazol-5-yl) phenyl]-8-ethyl-2-[4- (4-methylpiperazin-1-yl) anilino]pyrido[2,3-d]pyrimidin-7-one

Alternative Products

CatalogName
B1890-5FRAX597
A12553-10FRAX597 10mg
A12553-2FRAX597 2mg
A12553-1FRAX597 1mg
A12553-50FRAX597 50mg
A12553-100FRAX597 100mg

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