Ocaperidona

Ocaperidone, also known as R 79598, is a highly potent and efficacious dopamine-D2 antagonist with concomitant, equivalent serotonin 5-HT2 antagonism. Ocaperidone inhibited dopamine agonist (apomorphine, amphetamine or cocaine) -induced behavioral effects at low doses (0.014-0.042 mg/kg) . Ocaperidone completely blocked the dopamine agonist behavior at slightly higher doses (0.064 mg/kg) . Ocaperidone is expected to exert pronounced haloperidol-like effects on the positive symptoms of schizophrenic patients but with risperidone-like low extrapyramidal side effect liability and improved patient compliance. (In Vitro) :Ocaperidone has high affinify at 5-HT2 and dopamine D2, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5HT2, a1-adrenergic, dopamine D2, histamine H1 and a2-adrenergic, respectively. Ocaperidone shows 5-HT1A receptor agonist activity, with a pEC50 and pKi of 7.60 and 8.08. (In Vivo) :Ocaperidone shows a potent occupation of 5HT2 receptor via in vivo binding in the frontal cortex of rats with an ED50 of 0.04 mg/kg, and 0.1 4-0.1 6 mg/kg for D2 receptor in the striatum and the nucleus accumbens. Ocaperidone (R 79598) antagonizes dopamine D2 and 5-HT2, and shows a a partial generalization to buspirone with an ED50 of 0.163 mg/kg.

129029-23-8

Ocaperidone | R 79598 | R-79598 | R79598

>98% (HPLC)

In Vitro: DMSO : 16.67 mg/mL (39.65 mM)

Cc1cccn2c1nc (c (c2=O) CCN1CCC (CC1) c1noc2c1ccc (c2) F) C

C24H25FN4O2

420.49

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.