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KIN1148

CAT: 0013-GTR19160526-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160526-02Size:500 mg
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Description
KIN-1148 is a IRF3 agonist. IN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.
CAS Number
1428729-56-9
Product Name Alternative
KIN-1148 | KIN 1148 | KIN1148
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL. 276.67 mM
Smiles
O=C (NC1=NC2=CC=C3C (N=CS3) =C2S1) C4=CC5=C (C=C4) C=CC=C5
Molecular Formula
C19H11N3OS2
Molecular Weight
361.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (benzo[1,2-d:3,4-d']bis (thiazole) -2-yl) -2-naphthamide

Chemical Information

N-Benzo[1,2-d:3,4-d']bisthiazol-2-yl-2-naphthalenecarboxamide

KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.

CAS Number1428729-56-9
PubChem CID71549151
IUPAC NameN-([1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)naphthalene-2-carboxamide
Molecular FormulaC19H11N3OS2
Molecular Weight361.4
XLogP5.3
Topological Polar Surface Area111
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity519
SMILES
C1=CC=C2C=C(C=CC2=C1)C(=O)NC3=NC4=C(S3)C5=C(C=C4)SC=N5
InChI
InChI=1S/C19H11N3OS2/c23-18(13-6-5-11-3-1-2-4-12(11)9-13)22-19-21-14-7-8-15-16(17(14)25-19)20-10-24-15/h1-10H,(H,21,22,23)
InChIKey
YAISOECYKYATLL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Benzo[1,2-d:3,4-d']bisthiazol-2-yl-2-naphthalenecarboxamide
CAS: 1428729-56-9
CID: 71549151
Formula: C19H11N3OS2
MW: 361.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight361.4
XLogP35.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass361.03435433
Monoisotopic Mass361.03435433
Topological Polar Surface Area111 Ų
Heavy Atom Count25
Formal Charge0
Complexity519
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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